Not medical advice. This information is for educational purposes only. Always consult a qualified doctor or pharmacist before taking any medicine. Indomethacin requires a valid prescription.
Indomethacin
Generic Name: INDOMETHACIN
Indomethacin Capsules, USP are nonsteroidal anti-inflammatory drugs, available as capsules containing 25 mg and 50 mg of indomethacin, USP, administered for oral use.
Data last updated: 30 March 2026 · Source: openFDA.gov, DailyMed (NLM/NIH)
Common Brand Names in India:
What is Indomethacin Used For?
- Pain relief
- Fever reduction
- Anti-inflammatory
How Does It Work?
The mechanism of action of indomethacin capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Dosage & Administration
- After observing the response to initial therapy with indomethacin, the dose and frequency should be adjusted to suit an individual patient’s needs.
- Adverse reactions generally appear to correlate with the dose of indomethacin.
Side Effects
Common Side Effects
Serious Side Effects (seek immediate medical attention)
Warnings & Precautions
- Hepatotoxicity : Inform patients of warning signs and symptoms of hepatotoxicity.
- Monitor blood pressure. ( 5.4 , 7 ) Heart Failure and Edema : Avoid use of indomethacin capsules in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure. Renal Toxicity : Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia.
- Avoid use of indomethacin capsules in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function. Anaphylactic Reactions : Seek emergency help if an anaphylactic reaction occurs. Exacerbation of Asthma Related to Aspirin Sensitivity : Indomethacin capsules are contraindicated in patients with aspirin-sensitive asthma.
- Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs.
- The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease.
Who Should NOT Take This?
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
- Known hypersensitivity to indomethacin or any components of the drug product. ( 4 ) History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. ( 4 ) In the setting of CABG surgery. ( 4 )
Drug Interactions
Indomethacin may interact with the following medicines. Always inform your doctor about all medications you are taking.
Storage Instructions
Store at room temperature, away from moisture and heat.
Speak to a general physician on Zospital
Consult a general physician on Zospital before starting Indomethacin. Verified Indian specialists available for in-clinic and online consultations.
Other Analgesics & Pain Relief Medicines
Sources: openFDA.gov · dailymed.nlm.nih.gov · nlm.nih.gov (RxNorm). Information is for educational purposes only. Consult a doctor before use.
FAQS
Indomethacin – Frequently Asked Questions
Common questions about Indomethacin, its uses, dosage and safety.
Indomethacin is commonly prescribed in India for: Pain relief, Fever reduction, Anti-inflammatory. Always confirm the indication with a registered medical practitioner before starting any course.
Indomethacin is sold in India under brand names such as Tivorbex, Indocin, Indomethacin. You can also find it on online pharmacies like 1mg, Pharmeasy and Apollo Pharmacy.
Indomethacin is a prescription-only (Schedule H) medicine in India. You will need a valid prescription from a registered MBBS / MD doctor to purchase it from a licensed pharmacy.
Common side effects of Indomethacin can include: Nausea, Vomiting, Diarrhea, Constipation, Headache, Dizziness, Drowsiness, Fatigue. Less common but serious side effects can include: Serious, Fatal, Anaphylaxis, Anaphylactic, Hepatotoxicity. Stop the medicine and contact your doctor immediately if any of these appear.
The mechanism of action of indomethacin capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Indomethacin can interact with: Indomethacin, Clinical, Serotonin, Intervention, Aspirin, Angiotensin. Tell your doctor about every medicine, supplement and herbal product you take — including ayurvedic and homeopathy preparations — before starting Indomethacin.
Indian guidelines often recommend lower starting doses of Indomethacin for patients above 60-65, since kidney and liver function decline with age. A doctor should review the dose, especially if the patient already takes BP, sugar or heart medicines.
Pregnancy safety of Indomethacin depends on the trimester and individual case. Indian gynaecologists usually avoid Category C/D drugs unless benefit clearly outweighs risk. Speak to your obstetrician before taking Indomethacin during pregnancy or while planning conception.
Prices in India typically range from ₹10 – ₹120 per strip of 10 tablets depending on brand. Generic versions tend to cost 30-60% less than branded ones, and Jan Aushadhi outlets often stock the lowest-priced equivalents. Check 1mg or Pharmeasy for live MRP.
If you remember within a few hours of the missed dose, take it. If it is nearly time for the next dose, skip the missed one — never double up. Frequent missed doses reduce Indomethacin's effectiveness, so consider setting a reminder or speaking to your doctor about a simpler schedule.
You can book an in-person or online consultation with a verified Indian specialist on Zospital — visit the doctor directory at https://zospital.com/doctor to find one near you.
Medical Disclaimer
The content provided on Zospital is for general informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor or emergency services immediately.