Not medical advice. This information is for educational purposes only. Always consult a qualified doctor or pharmacist before taking any medicine. Zoledronic Acid requires a valid prescription.
Zoledronic Acid
Generic Name: ZOLEDRONIC ACID
Zoledronic acid injection contains zoledronic acid, a bisphosphonic acid which is an inhibitor of osteoclastic bone resorption.
Data last updated: 30 March 2026 · Source: openFDA.gov, DailyMed (NLM/NIH)
Common Brand Names in India:
What is Zoledronic Acid Used For?
- Prostate cancer should have progressed after treatment with at least one hormonal therapy.
How Does It Work?
Although the antiresorptive mechanism is not completely understood, several factors are thought to contribute to this action.
Dosage & Administration
- Hypercalcemia of malignancy 4 mg as a single-use intravenous infusion over no less than 15 minutes. 4 mg as retreatment after a minimum of 7 days.
- Multiple myeloma and bone metastasis from solid tumors. 4 mg as a single-use intravenous infusion over no less than 15 minutes every 3 to 4 weeks for patients with creatinine clearance of greater than 60 mL/min.
- Reduce the dose for patients with renal impairment.
Side Effects
Common Side Effects
Serious Side Effects (seek immediate medical attention)
Warnings & Precautions
- Patients being treated with zoledronic acid injection should not be treated with Reclast ® . Adequately rehydrate patients with hypercalcemia of malignancy prior to administration of zoledronic acid injection and monitor electrolytes during treatment. Renal toxicity may be greater in patients with renal impairment.
- Do not use doses greater than 4 mg.
- Avoid invasive dental procedures. Severe incapacitating bone, joint, and/or muscle pain may occur.
Who Should NOT Take This?
- Hypersensitivity to any component of zoledronic acid injection (4) Hypersensitivity to Zoledronic Acid or Any Components of Zoledronic Acid Injection Hypersensitivity reactions including rare cases of urticaria and angioedema, and very rare cases of anaphylactic reaction/shock have been reported [ see Adverse Reactions ].
Drug Interactions
Zoledronic Acid may interact with the following medicines. Always inform your doctor about all medications you are taking.
Storage Instructions
Store at room temperature, away from moisture and heat.
Speak to a orthopaedic doctor on Zospital
Consult a orthopaedic doctor on Zospital before starting Zoledronic Acid. Verified Indian specialists available for in-clinic and online consultations.
Other Bone & Joint Health Medicines
Sources: openFDA.gov · dailymed.nlm.nih.gov · nlm.nih.gov (RxNorm). Information is for educational purposes only. Consult a doctor before use.
FAQS
Zoledronic Acid – Frequently Asked Questions
Common questions about Zoledronic Acid, its uses, dosage and safety.
Zoledronic Acid is commonly prescribed in India for: Prostate cancer should have progressed after treatment with at least one hormonal therapy.. Always confirm the indication with a registered medical practitioner before starting any course.
Zoledronic Acid is sold in India under brand names such as Reclast, Zoledronic acid. You can also find it on online pharmacies like 1mg, Pharmeasy and Apollo Pharmacy.
Zoledronic Acid is a prescription-only (Schedule H) medicine in India. You will need a valid prescription from a registered MBBS / MD doctor to purchase it from a licensed pharmacy.
Common side effects of Zoledronic Acid can include: Nausea, Vomiting, Diarrhea, Constipation, Headache, Dizziness, Fatigue, Dry mouth. Less common but serious side effects can include: Severe, Anaphylactic, Seizure, Stevens-johnson, Renal failure. Stop the medicine and contact your doctor immediately if any of these appear.
Although the antiresorptive mechanism is not completely understood, several factors are thought to contribute to this action.
Zoledronic Acid can interact with: Calcitonin, Caution, Thalidomide, Coadministration. Tell your doctor about every medicine, supplement and herbal product you take — including ayurvedic and homeopathy preparations — before starting Zoledronic Acid.
Indian guidelines often recommend lower starting doses of Zoledronic Acid for patients above 60-65, since kidney and liver function decline with age. A doctor should review the dose, especially if the patient already takes BP, sugar or heart medicines.
Pregnancy safety of Zoledronic Acid depends on the trimester and individual case. Indian gynaecologists usually avoid Category C/D drugs unless benefit clearly outweighs risk. Speak to your obstetrician before taking Zoledronic Acid during pregnancy or while planning conception.
Prices in India typically range from ₹30 – ₹500 per strip / vial depending on brand. Generic versions tend to cost 30-60% less than branded ones, and Jan Aushadhi outlets often stock the lowest-priced equivalents. Check 1mg or Pharmeasy for live MRP.
If you remember within a few hours of the missed dose, take it. If it is nearly time for the next dose, skip the missed one — never double up. Frequent missed doses reduce Zoledronic Acid's effectiveness, so consider setting a reminder or speaking to your doctor about a simpler schedule.
You can book an in-person or online consultation with a verified Indian specialist on Zospital — visit the doctor directory at https://zospital.com/doctor to find one near you.
Medical Disclaimer
The content provided on Zospital is for general informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor or emergency services immediately.