Not medical advice. This information is for educational purposes only. Always consult a qualified doctor or pharmacist before taking any medicine. Denosumab requires a valid prescription.
Denosumab
Generic Name: DENOSUMAB-BMWO
Denosumab-bmwo is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand).
Data last updated: 30 March 2026 · Source: openFDA.gov, DailyMed (NLM/NIH)
Common Brand Names in India:
What is Denosumab Used For?
- Postmenopausal women with osteoporosis at high risk for fracture
How Does It Work?
Denosumab products prevent RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors.
Dosage & Administration
- The recommended dose of Stoboclo is 60 mg administered as a single subcutaneous injection once every 6 months.
- Administer Stoboclo via subcutaneous injection in the upper arm, the upper thigh, or the abdomen.
Side Effects
Common Side Effects
Serious Side Effects (seek immediate medical attention)
Warnings & Precautions
- Hypocalcemia: Pre-existing hypocalcemia must be corrected before initiating Stoboclo.
- Concomitant use of calcimimetic drugs may also worsen hypocalcemia risk.
- Monitor serum calcium. Same Active Ingredient: Patients receiving Stoboclo should not receive other denosumab products concomitantly. Hypersensitivity including anaphylactic reactions may occur.
Who Should NOT Take This?
- Pregnant women: Denosumab products may cause fetal harm when administered to a pregnant woman.
- In women of reproductive potential, pregnancy testing should be performed prior to initiating treatment with Stoboclo [see Use in Specific Populations ] .
- Patients with hypersensitivity to denosumab products: Stoboclo is contraindicated in patients with a history of systemic hypersensitivity to any component of the product.
- Hypocalcemia ( 4 , 5.1 ) Pregnancy ( 4 , 8.1 ) Known hypersensitivity to denosumab products ( 4 , 5.3 )
Storage Instructions
Storage and Handling Store Stoboclo refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
Speak to a orthopaedic doctor on Zospital
Consult a orthopaedic doctor on Zospital before starting Denosumab. Verified Indian specialists available for in-clinic and online consultations.
Other Bone & Joint Health Medicines
Sources: openFDA.gov · dailymed.nlm.nih.gov · nlm.nih.gov (RxNorm). Information is for educational purposes only. Consult a doctor before use.
FAQS
Denosumab – Frequently Asked Questions
Common questions about Denosumab, its uses, dosage and safety.
Denosumab is commonly prescribed in India for: Postmenopausal women with osteoporosis at high risk for fracture. Always confirm the indication with a registered medical practitioner before starting any course.
Denosumab is sold in India under brand names such as Xgeva, Wyost, Jubbonti, Conexxence, Stoboclo. You can also find it on online pharmacies like 1mg, Pharmeasy and Apollo Pharmacy.
Denosumab is a prescription-only (Schedule H) medicine in India. You will need a valid prescription from a registered MBBS / MD doctor to purchase it from a licensed pharmacy.
Common side effects of Denosumab can include: Vomiting, Constipation, Headache, Dizziness, Insomnia, Rash, Abdominal pain, Back pain. Less common but serious side effects can include: Severe, Serious, Life-threatening, Fatal, Death. Stop the medicine and contact your doctor immediately if any of these appear.
Denosumab products prevent RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors.
Indian guidelines often recommend lower starting doses of Denosumab for patients above 60-65, since kidney and liver function decline with age. A doctor should review the dose, especially if the patient already takes BP, sugar or heart medicines.
Pregnancy safety of Denosumab depends on the trimester and individual case. Indian gynaecologists usually avoid Category C/D drugs unless benefit clearly outweighs risk. Speak to your obstetrician before taking Denosumab during pregnancy or while planning conception.
Prices in India typically range from ₹30 – ₹500 per strip / vial depending on brand. Generic versions tend to cost 30-60% less than branded ones, and Jan Aushadhi outlets often stock the lowest-priced equivalents. Check 1mg or Pharmeasy for live MRP.
If you remember within a few hours of the missed dose, take it. If it is nearly time for the next dose, skip the missed one — never double up. Frequent missed doses reduce Denosumab's effectiveness, so consider setting a reminder or speaking to your doctor about a simpler schedule.
You can book an in-person or online consultation with a verified Indian specialist on Zospital — visit the doctor directory at https://zospital.com/doctor to find one near you.
Medical Disclaimer
The content provided on Zospital is for general informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor or emergency services immediately.