Not medical advice. This information is for educational purposes only. Always consult a qualified doctor or pharmacist before taking any medicine. Isotretinoin requires a valid prescription.
Isotretinoin
Generic Name: ISOTRETINOIN
DESCRIPTION Isotretinoin, a retinoid, is available as isotretinoin capsules in 10-mg, 20-mg, 30-mg and 40-mg soft gelatin capsules for oral administration.
Data last updated: 30 March 2026 · Source: openFDA.gov, DailyMed (NLM/NIH)
Common Brand Names in India:
What is Isotretinoin Used For?
- Severe recalcitrant nodular acne
- Nodules are inflammatory lesions with a diameter of 5 mm or greater.
How Does It Work?
The exact mechanism of action of isotretinoin is unknown.
Dosage & Administration
- The recommended dosage range for isotretinoin capsules are 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks.
- In studies comparing 0.1, 0.5, and 1 mg/kg/day 8 , it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages.
- During treatment, the dose may be adjusted according to response of the disease and/or the appearance of clinical side effects – some of which may be dose related.
Side Effects
Common Side Effects
Serious Side Effects (seek immediate medical attention)
Warnings & Precautions
- While such monitoring may be helpful, it may not detect all patients at risk.
Who Should NOT Take This?
- CONTRAINDICATIONS Pregnancy Category X See Boxed CONTRAINDICATIONS AND WARNINGS .
Drug Interactions
Isotretinoin may interact with the following medicines. Always inform your doctor about all medications you are taking.
Storage Instructions
Storage Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature].
Speak to a dermatologist on Zospital
Consult a dermatologist on Zospital before starting Isotretinoin. Verified Indian specialists available for in-clinic and online consultations.
Other Skin & Dermatology Medicines
Sources: openFDA.gov · dailymed.nlm.nih.gov · nlm.nih.gov (RxNorm). Information is for educational purposes only. Consult a doctor before use.
FAQS
Isotretinoin – Frequently Asked Questions
Common questions about Isotretinoin, its uses, dosage and safety.
Isotretinoin is commonly prescribed in India for: Severe recalcitrant nodular acne, Nodules are inflammatory lesions with a diameter of 5 mm or greater.. Always confirm the indication with a registered medical practitioner before starting any course.
Isotretinoin is sold in India under brand names such as Accutane, Sotret, Oratane, Isol, Myorisan, Absorica. You can also find it on online pharmacies like 1mg, Pharmeasy and Apollo Pharmacy.
Isotretinoin is a prescription-only (Schedule H) medicine in India. You will need a valid prescription from a registered MBBS / MD doctor to purchase it from a licensed pharmacy.
Common side effects of Isotretinoin can include: Nausea, Headache, Dizziness, Drowsiness, Fatigue, Dry mouth, Insomnia, Rash. Less common but serious side effects can include: Severe, Hepatotoxicity, Agranulocytosis, Suicidal, Seizure. Stop the medicine and contact your doctor immediately if any of these appear.
The exact mechanism of action of isotretinoin is unknown.
Isotretinoin can interact with: Vitamin, Isotretinoin, Phenytoin. Tell your doctor about every medicine, supplement and herbal product you take — including ayurvedic and homeopathy preparations — before starting Isotretinoin.
Indian guidelines often recommend lower starting doses of Isotretinoin for patients above 60-65, since kidney and liver function decline with age. A doctor should review the dose, especially if the patient already takes BP, sugar or heart medicines.
Pregnancy safety of Isotretinoin depends on the trimester and individual case. Indian gynaecologists usually avoid Category C/D drugs unless benefit clearly outweighs risk. Speak to your obstetrician before taking Isotretinoin during pregnancy or while planning conception.
Prices in India typically range from ₹30 – ₹500 per strip / vial depending on brand. Generic versions tend to cost 30-60% less than branded ones, and Jan Aushadhi outlets often stock the lowest-priced equivalents. Check 1mg or Pharmeasy for live MRP.
If you remember within a few hours of the missed dose, take it. If it is nearly time for the next dose, skip the missed one — never double up. Frequent missed doses reduce Isotretinoin's effectiveness, so consider setting a reminder or speaking to your doctor about a simpler schedule.
You can book an in-person or online consultation with a verified Indian specialist on Zospital — visit the doctor directory at https://zospital.com/doctor to find one near you.
Medical Disclaimer
The content provided on Zospital is for general informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor or emergency services immediately.