Not medical advice. This information is for educational purposes only. Always consult a qualified doctor or pharmacist before taking any medicine. Ezetimibe requires a valid prescription.
Ezetimibe
Generic Name: EZETIMIBE AND SIMVASTATIN
Ezetimibe and simvastatin tablets contain ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, an HMG-CoA reductase inhibitor.
Data last updated: 30 March 2026 · Source: openFDA.gov, DailyMed (NLM/NIH)
Common Brand Names in India:
What is Ezetimibe Used For?
- Elevated total cholesterol (total-C)
How Does It Work?
Ezetimibe and simvastatin tablets contain ezetimibe and simvastatin, two lipid-lowering compounds with complementary mechanisms of action.
Dosage & Administration
- The recommended usual starting dose is 10 mg/10 mg/day or 10 mg/20 mg/day.
- Ezetimibe and simvastatin tablets should be taken as a single daily dose in the evening, with or without food.
- Patients who require a larger reduction in LDL-C (greater than 55%) may be started at 10 mg/40 mg/day in the absence of moderate to severe renal impairment (estimated glomerular filtration rate less than 60 mL/min/1.73 m 2 ).
Side Effects
Common Side Effects
Serious Side Effects (seek immediate medical attention)
Warnings & Precautions
- Patients should be advised of the increased risk of myopathy, including rhabdomyolysis, with the 10 mg/80 mg dose. Patients should be advised to report promptly any unexplained and/or persistent muscle pain, tenderness, or weakness.
- Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with higher doses and concomitant use of certain medicines.
- The risk of myopathy is increased elevated plasma levels of simvastatin and simvastatin acid.
Who Should NOT Take This?
- Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development.
- Because HMG-CoA reductase inhibitors (statins), such as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, ezetimibe and simvastatin tablets may cause fetal harm when administered to a pregnant woman.
- Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia.
- In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity.
Drug Interactions
Ezetimibe may interact with the following medicines. Always inform your doctor about all medications you are taking.
Storage Instructions
Store at room temperature, away from moisture and heat.
Speak to a cardiologist on Zospital
Consult a cardiologist on Zospital before starting Ezetimibe. Verified Indian specialists available for in-clinic and online consultations.
Other Cardiovascular Medicines
Sources: openFDA.gov · dailymed.nlm.nih.gov · nlm.nih.gov (RxNorm). Information is for educational purposes only. Consult a doctor before use.
FAQS
Ezetimibe – Frequently Asked Questions
Common questions about Ezetimibe, its uses, dosage and safety.
Ezetimibe is commonly prescribed in India for: Elevated total cholesterol (total-C). Always confirm the indication with a registered medical practitioner before starting any course.
Ezetimibe is sold in India under brand names such as Nexlizet, Roszet, Zetia, Vytorin, Ezetimibe and Simvastatin. You can also find it on online pharmacies like 1mg, Pharmeasy and Apollo Pharmacy.
Ezetimibe is a prescription-only (Schedule H) medicine in India. You will need a valid prescription from a registered MBBS / MD doctor to purchase it from a licensed pharmacy.
Common side effects of Ezetimibe can include: Nausea, Vomiting, Diarrhea, Constipation, Headache, Dizziness, Fatigue, Insomnia. Less common but serious side effects can include: Serious, Fatal, Anaphylaxis, Stevens-johnson, Rhabdomyolysis. Stop the medicine and contact your doctor immediately if any of these appear.
Ezetimibe and simvastatin tablets contain ezetimibe and simvastatin, two lipid-lowering compounds with complementary mechanisms of action.
Ezetimibe can interact with: Clinical, Simvastatin, Niacin, Verapamil, Lomitapide, Daptomycin. Tell your doctor about every medicine, supplement and herbal product you take — including ayurvedic and homeopathy preparations — before starting Ezetimibe.
Indian guidelines often recommend lower starting doses of Ezetimibe for patients above 60-65, since kidney and liver function decline with age. A doctor should review the dose, especially if the patient already takes BP, sugar or heart medicines.
Pregnancy safety of Ezetimibe depends on the trimester and individual case. Indian gynaecologists usually avoid Category C/D drugs unless benefit clearly outweighs risk. Speak to your obstetrician before taking Ezetimibe during pregnancy or while planning conception.
Prices in India typically range from ₹30 – ₹250 per strip of 10 tablets depending on brand. Generic versions tend to cost 30-60% less than branded ones, and Jan Aushadhi outlets often stock the lowest-priced equivalents. Check 1mg or Pharmeasy for live MRP.
If you remember within a few hours of the missed dose, take it. If it is nearly time for the next dose, skip the missed one — never double up. Frequent missed doses reduce Ezetimibe's effectiveness, so consider setting a reminder or speaking to your doctor about a simpler schedule.
You can book an in-person or online consultation with a verified Indian specialist on Zospital — visit the doctor directory at https://zospital.com/doctor to find one near you.
Medical Disclaimer
The content provided on Zospital is for general informational and educational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call your doctor or emergency services immediately.